Cellular identity crisis: Antiandrogen resistance by lineage plasticity
نویسندگان
چکیده
منابع مشابه
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.
Some cancers evade targeted therapies through a mechanism known as lineage plasticity, whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the drug target. We use in vitro and in vivo human prostate cancer models to show that these tumors can develop resistance to the antiandrogen drug enzalutamide by a phenotypic shift from androgen rece...
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Frailty is a common and central problem of old age. Recent research has defined frailty as an accumulation of deficits or as a distinct clinical syndrome involving specific comorbid physical disorders and functional impairment, but the psychological aspects of frailty have received little attention. It is proposed that the onset of frailty is associated with an identity crisis, a psychological ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2017
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2017.1323599